Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad IM
PROVIDER: S-EPMC8125955 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Ahmad Iman M IM Dafferner Alicia J AJ O'Connell Kelly A KA Mehla Kamiya K Britigan Bradley E BE Hollingsworth Michael A MA Abdalla Maher Y MY
Cancers 20210508 9
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Tumor hypoxia plays an active role in promoting tumor progression, malignancy, and resistance to therapy in PDAC. We present evidence that nab-paclitaxel-gemcitabine (NPG) and/or a hypoxic tumor microenvironment (TME) up-regulate heme oxygenase-1 (HO-1), providing a survival advantage for tumors. Using PDAC cells in vitro and a PDAC mouse model, we found that NPG chemotherapy up-regulated expression of HO- ...[more]