Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response.

ABSTRACT:

Background

A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability. Ideally, if A and B are two synthetic lethal genes, inhibiting B should kill cancer cells with a defect on A, and should have no effects on normal cells. Thus, synthetic lethality can be exploited for highly selective cancer therapies, which need to exploit differences between normal and cancer cells.

Results

In this paper, we present a new method for predicting synthetic lethal (SL) gene pairs. As neighbouring genes in the genome have highly correlated profiles of copy number variations (CNAs), our method clusters proximal genes with a similar CNA profile, then predicts mutually exclusive group pa

SUBMITTER: Pinoli P 

PROVIDER: S-EPMC8126165 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature