Contribution of Matrix Metalloproteinase-1 Genotypes to Colorectal Cancer in Taiwan.

ABSTRACT:

Background/aim

Matrix metalloproteinase-1 is responsible for extracellular matrix regulation, and its genetic role in colorectal cancer (CRC) is unclear. The aim of the study was to investigate the contribution of Matrix metalloproteinase-1 genotypes to CRC risk in Taiwan.

Materials and methods

A total of 362 cases and 362 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined. The environmental factors and clinical-pathological records were also analyzed.

Results

The genotypic frequency of MMP-1 rs1799750 were different between the CRC and control groups (p for trend=0.0083). 1G/2G and 1G/1G were associated with lower risk (p=0.0438 and 0.0030, adjusted OR=0.73 and 0.54, 95%CI=0.54-0.90 and 0.37-0.83). Among non-smokers, those with 1G/2G and

SUBMITTER: Wu MH 

PROVIDER: S-EPMC8126333 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature