Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis.

ABSTRACT:

Background

Cycloserine, or its structural analogue terizidone, has been associated with neuropsychiatric toxicity (psychosis, depression, and neuropathy). Prospective clinical data on the incidence of and risk factors for neuropsychiatric toxicity in TB patients treated with cycloserine are limited.

Methods

A prospective evaluation of neuropsychiatric toxicity was performed using validated screening tools in patients with multidrug-resistant tuberculosis treated with terizidone. Cox proportional hazard modelling was performed to explore the effects of clinical variables and measures of cycloserine pharmacokinetics in plasma.

Results

A total 144 participants were recruited: 86 were male and 58 were female; their median age was 35.7 years and 91 (63%) were HIV-infected.

SUBMITTER: Court R 

PROVIDER: S-EPMC8126338 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature