Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis.

ABSTRACT:

Background

The outcomes of deep vein thrombosis (DVT) in children with May-Thurner Syndrome (MTS) remain unclear.

Objectives

This systematic review and patient-level meta-analysis aims to describe the outcomes of children with MTS presenting with DVT.

Methods

A systematic review of the published literature was performed. Data related to patients <18 years diagnosed with MTS and DVT was extracted. Risk of bias was assessed using the Murad criteria. Outcomes included vessel patency post-treatment, DVT recurrence, and post-thrombotic syndrome (PTS). Predictive and explanatory models were developed for these outcomes.

Results

In total, 109 cases were identified (age range 4-17 years; 77 females) in 28 studies; 75% of patients had ≥1 additional risk factor for DVT.

SUBMITTER: Avila L 

PROVIDER: S-EPMC8126469 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature