The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats.

ABSTRACT:

Background

Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage. We hypothesized that as a consequence of vascular leakage, renal perfusion and function is impaired and that activating Tie2 restores renal perfusion and function.

Methods

Rats underwent 1 h of hemorrhagic shock and were treated with either vasculotide or PBS as control, followed by fluid resuscitation for 4 h. Microcirculatory perfusion was measured in the renal cortex and cremaster muscle using contrast echography and intravital microscopy, respectively. Changes in the angiopoietin/Tie2 system and renal injury markers were meas

SUBMITTER: van Leeuwen ALI 

PROVIDER: S-EPMC8126531 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature