Survival After Trimodality Therapy in Patients With Locally Advanced Esophagogastric Adenocarcinoma: Does Only a Complete Pathologic Response Matter?

ABSTRACT:

Objective

To evaluate whether pCR exclusively defines major pathologic response to treatment with improved survival.

Summary background data

pCR after trimodality therapy for EAC is infrequent but associated with improved prognosis. Yet most clinical trials and correlative studies designate pCR as the primary endpoint.

Methods

We analyzed our prospectively maintained database for patients who underwent trimodality therapy for locally advanced esophageal adeno-carcinoma between 1995 and 2017. Overall survival (OS) was examined by percentage TR in the primary tumor bed and pathologic nodal stage (ypN0) using Kaplan-Meier plots. Optimal thresholds of TR for differentiating patients in terms of OS were investigated with descriptive plots using restricted cubic spline func

SUBMITTER: Sihag S 

PROVIDER: S-EPMC8126574 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature