Multimodality molecular imaging: Gaining insights into the mechanisms linking chronic stress to cardiovascular disease.

ABSTRACT: Positron emission tomography (PET) imaging can yield unique mechanistic insights into the pathophysiology of atherosclerosis. ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG), a radiolabeled glucose analog, is retained by cells in proportion to their glycolytic activity. While ¹⁸F-FDG accumulates within several cell types in the arterial wall, its retention correlates with macrophage content, providing an index of arterial inflammation (ArtI) which predicts subsequent cardiovascular disease (CVD) events. Furthermore, ¹⁸F-FDG-PET imaging allows the simultaneous assessment of metabolic activity in several tissues (e.g., brain, bone marrow) and is performed in conjunction with cross-sectional imaging that enables multi-organ structural assessments. Accordingly,

SUBMITTER: Osborne MT 

PROVIDER: S-EPMC8126581 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature