The Consumption of Energy Drinks Induces Blood-Brain Barrier Dysfunction in Wild-Type Mice.

ABSTRACT: Energy drinks containing significant quantities of caffeine and sugar are increasingly consumed, particularly by adolescents and young adults. Chronic ingestion of energy drinks may potentially regulate vascular risk factors. This study investigated the effects of chronic ingestion of energy drinks on blood-brain barrier (BBB) integrity and neuroinflammation. Male C57BL/6J mice were maintained on water (control), Mother^TM (ED), sugar-free Mother^TM (sfED), or Coca Cola^TM soft drink (SD) for 13 weeks. The BBB integrity and neuroinflammation were analyzed with semi-quantitative immunofluorescent microscopy. Blood pressure, plasma inflammatory cytokine levels and blood glucose were also considered. Following 13 weeks of intervention, mice treated with ED, sfED,

SUBMITTER: Graneri L 

PROVIDER: S-EPMC8126614 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature