Increased Dysfunctional and Plastic Regulatory T Cells in Idiopathic Orbital Inflammation.

ABSTRACT:

Background

Idiopathic orbital inflammation (IOI) is a disfiguring and vision-threatening fibroinflammatory disorder. The pathogenesis of IOI has not been elucidated. We sought to clarify the regulatory T cell (Treg) distribution and function in patients with IOI.

Methods

The frequency, phenotype and function of Tregs were identified by multicolor flow cytometry and in vitro cell functional assays. Plasma and tissue samples were obtained to investigate cytokines, chemokines and their receptors of interest by relative real-time polymerase chain reaction (PCR) and Luminex assays.

Results

Compared with healthy subjects, patients with IOI exhibited obvious increases of Tregs in peripheral blood and affected orbital tissues. Circulating Tregs from patients with IOI w

SUBMITTER: Chen J 

PROVIDER: S-EPMC8126653 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature