Structural Profiling of Bacterial Effectors Reveals Enrichment of Host-Interacting Domains and Motifs.

ABSTRACT: Effector proteins are bacterial virulence factors secreted directly into host cells and, through extensive interactions with host proteins, rewire host signaling pathways to the advantage of the pathogen. Despite the crucial role of globular domains as mediators of protein-protein interactions (PPIs), previous structural studies of bacterial effectors are primarily focused on individual domains, rather than domain-mediated PPIs, which limits their ability to uncover systems-level molecular recognition principles governing host-bacteria interactions. Here, we took an interaction-centric approach and systematically examined the potential of structural components within bacterial proteins to engage in or target eukaryote-specific domain-domain interactions (DDIs). Our results indicate that: 1

SUBMITTER: Chen YF 

PROVIDER: S-EPMC8126662 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature