IL-14α as a Putative Biomarker for Stratification of Dry Eye in Primary Sjogren's Syndrome.

ABSTRACT:

Background

Dry eye is often the first presenting manifestation of primary Sjögren's syndrome (pSS). Because of the high prevalence of dry eye disease in normal population, ophthalmologists urgently need a non-invasive and reliable screening test to diagnose dry eye associated SS patients, other than ocular symptoms and signs. Currently, there is no single test available. The correlation of serum IL-14α with pSS has been found in pSS mouse model.

Purpose

To evaluate whether IL-14α can serve as a biomarker to stratify dry eye in primary Sjögren's syndrome and its correlation to BAFF in a cohort of patients with non-SS dry eye (NSDE), pSS with dry eye disease, rheumatoid arthritis (RA), and healthy controls (HC).

Methods

Retrospective study based on serum levels of IL-14

SUBMITTER: Liang Y 

PROVIDER: S-EPMC8126710 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature