Differentiation and Regulation of T_H Cells: A Balancing Act for Cancer Immunotherapy.

ABSTRACT: Current success of immunotherapy in cancer has drawn attention to the subsets of T_H cells in the tumor which are critical for activation of anti-tumor response either directly by themselves or by stimulating cytotoxic T cell activity. However, presence of immunosuppressive pro-tumorigenic T_H subsets in the tumor milieu further contributes to the complexity of regulation of T_H cell-mediated immune response. In this review, we present an overview of the multifaceted positive and negative effects of T_H cells, with an emphasis on regulation of different T_H cell subtypes by various immune cells, and how a delicate balance of contradictory signals can influence overall success of cancer immunotherapy. We focus on the regulatory network that

SUBMITTER: Basu A 

PROVIDER: S-EPMC8126720 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature