Treatment of Noninfectious Retinal Vasculitis Using Subcutaneous Repository Corticotropin Injection.

ABSTRACT:

Purpose

To show whether subcutaneous repository corticotropin injection (RCI, Acthar® Gel, a repository corticotropin injection, can be an effective potential therapeutic agent for noninfectious retinal vasculitis.

Methods

Patients with active retinal vasculitis were followed with serial ultra-wide-field fluorescein angiograms and treated with 80 units of subcutaneous repository corticotropin injection twice weekly.

Results

Primary outcome of ≥ 50% improvement in response level (RL) for retinal vasculitis and percent improvement in retinal vasculitis severity scoring (RVSS) by more than one quartile ( ≥ 25%) at week 12 was met in 15 and 16 of the 30 total eyes, respectively, including 1 eye with severe retinal vasculitis in each group. Complete resolution of retinal v

SUBMITTER: Anesi SD 

PROVIDER: S-EPMC8126741 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature