Compliant 3D frameworks instrumented with strain sensors for characterization of millimeter-scale engineered muscle tissues.

ABSTRACT: Tissue-on-chip systems represent promising platforms for monitoring and controlling tissue functions in vitro for various purposes in biomedical research. The two-dimensional (2D) layouts of these constructs constrain the types of interactions that can be studied and limit their relevance to three-dimensional (3D) tissues. The development of 3D electronic scaffolds and microphysiological devices with geometries and functions tailored to realistic 3D tissues has the potential to create important possibilities in advanced sensing and control. This study presents classes of compliant 3D frameworks that incorporate microscale strain sensors for high-sensitivity measurements of contractile forces of engineered optogenetic muscle tissue rings, supported by quantitative simulations. Compared with

SUBMITTER: Zhao H 

PROVIDER: S-EPMC8126769 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature