Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.

ABSTRACT: Drug resistance is prevalent across many diseases, rendering therapies ineffective with severe financial and health consequences. Rather than accepting resistance after the fact, proactive strategies need to be incorporated into the drug design and development process to minimize the impact of drug resistance. These strategies can be derived from our experience with viral disease targets where multiple generations of drugs had to be developed to combat resistance and avoid antiviral failure. Significant efforts including experimental and computational structural biology, medicinal chemistry, and machine learning have focused on understanding the mechanisms and structural basis of resistance against direct-acting antiviral (DAA) drugs. Integrated methods show promise for being predictive of

SUBMITTER: Matthew AN 

PROVIDER: S-EPMC8126998 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature