Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment.

ABSTRACT: Humans are exposed to a myriad of chemical substances in both occupational and environmental settings. Persistent organic pollutants (POPs) have drawn attention for their adverse effects including cancer and endocrine disruption. Herein, the objectives were 1) to describe serum and adipose tissue retinol levels, along with serum retinol binding protein 4 (RBP4) concentrations, and 2) to assess the associations of adipose tissue POP levels with these retinoid parameters, as well as their potential interaction with the previously-observed POP-related disruption of redox microenvironment. Retinol was measured in both serum and adipose tissue along with RBP4 levels in serum samples of 236 participants of the GraMo adult cohort. Associations were explored by multivariable linear regression anal

SUBMITTER: Galban-Velazquez S 

PROVIDER: S-EPMC8127078 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature