Plasma metabolites to profile pathways in noncommunicable disease multimorbidity.

ABSTRACT: Multimorbidity, the simultaneous presence of multiple chronic conditions, is an increasing global health problem and research into its determinants is of high priority. We used baseline untargeted plasma metabolomics profiling covering >1,000 metabolites as a comprehensive readout of human physiology to characterize pathways associated with and across 27 incident noncommunicable diseases (NCDs) assessed using electronic health record hospitalization and cancer registry data from over 11,000 participants (219,415 person years). We identified 420 metabolites shared between at least 2 NCDs, representing 65.5% of all 640 significant metabolite-disease associations. We integrated baseline data on over 50 diverse clinical risk factors and characteristics to identify actionable shared pathways re

SUBMITTER: Pietzner M 

PROVIDER: S-EPMC8127079 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature