The effect of risperidone on reward-related brain activity is robust to drug-induced vascular changes.

ABSTRACT: Dopamine (DA) mediated brain activity is intimately linked to reward-driven cerebral responses, while aberrant reward processing has been implicated in several psychiatric disorders. fMRI has been a valuable tool in understanding the mechanism by which DA modulators alter reward-driven responses and how they may exert their therapeutic effect. However, the potential effects of a pharmacological compound on aspects of neurovascular coupling may cloud the interpretability of the BOLD contrast. Here, we assess the effects of risperidone on reward driven BOLD signals produced by reward anticipation and outcome, while attempting to control for potential drug effects on regional cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). Healthy male volunteers (n = 21) each received a singl

SUBMITTER: Hawkins PCT 

PROVIDER: S-EPMC8127149 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature