Cortical and subcortical responsiveness to intensive adaptive working memory training: An MRI surface-based analysis.

ABSTRACT: Working memory training (WMT) has been shown to have effects on cognitive performance, the precise effects and the underlying neurobiological mechanisms are, however, still a matter of debate. In particular, the impact of WMT on gray matter morphology is still rather unclear. In the present study, 59 healthy middle-aged participants (age range 50-65 years) were pseudo-randomly single-blinded allocated to an 8-week adaptive WMT or an 8-week nonadaptive intervention. Before and after the intervention, high resolution magnetic resonance imaging (MRI) was performed and cognitive test performance was assessed in all participants. Vertex-wise cortical volume, thickness, surface area, and cortical folding was calculated. Seven subcortical volumes of interest and global mean cortical thickness wer

SUBMITTER: Wu Q 

PROVIDER: S-EPMC8127158 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature