Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.

ABSTRACT: The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub-state where integration predominates, and a predominantly segregated sub-state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional connectivity to compare resting-state functional MRI data from healthy volunteers before, during, and after loss of responsiveness induced with different concentrations of the inhalational anaesthetic, sevoflurane. We show that dynamic states characterised by high brain integration are especially vulnerable to general anaesthesia, exhibiting attenuated complexity and diminished small-world character. Crucially, these ef

SUBMITTER: Luppi AI 

PROVIDER: S-EPMC8127159 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature