Serum levels of miR-21-5p and miR-339-5p associate with occupational trichloroethylene hypersensitivity syndrome.

ABSTRACT:

Background

Trichloroethylene (TCE) hypersensitivity syndrome (THS) is a dose-independent and potentially life-threatening disease. In this study, we sought to identify THS-related miRNAs and evaluate its potential clinical value.

Methods

Serum samples of five patients and five matched TCE contacts were used for screening differential miRNAs. Another 34 patients and 34 matched TCE contacts were used for verifying significantly differential miRNAs with SYBR™ Green PCR and MGB PCR. The diagnostic model based on these miRNAs was established via the support vector machine (SVM) algorithm. Correlation between differential miRNAs and liver function was analyzed via the Spearman correlation test.

Results

A total of 69 miRNAs was found to be differentially expressed. MiR-21-5p

SUBMITTER: Liu W 

PROVIDER: S-EPMC8127200 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature