CCL21 activation of the MALAT1/SRSF1/mTOR axis underpins the development of gastric carcinoma.

ABSTRACT:

Background

As a significant cause of malignancy mortality, gastric carcinoma (GC) has been well documented to be an often-fatal diagnosis. Despite the limitations of effective therapy, immunotherapy has emerged as a promising therapeutic approach capable of killing cancer cells via the immune system. The current study was conducted to investigate the effect of cytokine C-C motif chemokine ligand 21 (CCL21) on GC progression through the metastasis-associated lung adenocarcinoma transcript 1/serine arginine-rich splicing factor 1/mammalian target of rapamycin (MALAT1/SRSF1/mTOR) axis.

Methods

Bioinformatics analysis was conducted to identify the key genes associated with GC and to subsequently predict their downstream genes. The effect of CCL21, MALAT1, and SRSF1 on the malign

SUBMITTER: Fu Q 

PROVIDER: S-EPMC8127212 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature