Rapid protein sequence evolution via compensatory frameshift is widespread in RNA virus genomes.

ABSTRACT:

Background

RNA viruses possess remarkable evolutionary versatility driven by the high mutability of their genomes. Frameshifting nucleotide insertions or deletions (indels), which cause the premature termination of proteins, are frequently observed in the coding sequences of various viral genomes. When a secondary indel occurs near the primary indel site, the open reading frame can be restored to produce functional proteins, a phenomenon known as the compensatory frameshift.

Results

In this study, we systematically analyzed publicly available viral genome sequences and identified compensatory frameshift events in hundreds of viral protein-coding sequences. Compensatory frameshift events resulted in large-scale amino acid differences between the compensatory frameshift form a

SUBMITTER: Park D 

PROVIDER: S-EPMC8127213 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature