Identification of 4-genes model in papillary renal cell tumor microenvironment based on comprehensive analysis.

ABSTRACT:

Background

The tumor microenvironment acts a pivotal part in the occurrence and development of tumor. However, there are few studies on the microenvironment of papillary renal cell carcinoma (PRCC). Our study aims to explore prognostic genes related to tumor microenvironment in PRCC.

Methods

PRCC expression profiles and clinical data were extracted from The Cancer Gene Atlas (TCGA) and Gene Expression Omnibus (GEO) database. Immune/stromal scores were performed utilizing the ESTIMATE algorithm. Three hundred fifty-seven samples were split into two groups on the basis of median immune/stromal score, and comparison of gene expression was conducted. Intersect genes were obtained by Venn diagrams. Hub genes were selected through protein-protein interaction (PPI) network construc

SUBMITTER: Luo L 

PROVIDER: S-EPMC8127234 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature