Structural landscape of the complete genomes of dengue virus serotypes and other viral hemorrhagic fevers.

ABSTRACT:

Background

With more than 300 million potentially infected people every year, and with the expanded habitat of mosquitoes due to climate change, Dengue virus (DENV) cannot be considered anymore only a tropical disease. The RNA secondary structure is a functional characteristic of RNA viruses, and together with the accumulated high-throughput sequencing data could provide general insights towards understanding virus biology. Here, we profiled the RNA secondary structure of > 7000 complete viral genomes from 11 different species focusing on viral hemorrhagic fevers, including DENV serotypes, EBOV, and YFV.

Results

In our work we demonstrated that the secondary structure and presence of protein-binding domains in the genomes can be used as intrinsic signature to further classif

SUBMITTER: Delli Ponti R 

PROVIDER: S-EPMC8127238 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature