Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning.

ABSTRACT: The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physical function and body composition. Two independent cohorts (N = 139 and N = 47) were included, whose age span covered adulthood (23-69 years). Whole blood and m. vastus lateralis samples were collected, and DNA methylation was analysed. Four different DNA methylation age (DNAmAge) estimates were calculated using genome-wide methylation data and publicly available online tools. A novel muscle-specific methylation age was estimated using the R-package 'MEAT'. PA was measured with questionnaires and accelerometers. Several tests were conducted to estimate cardiorespiratory fitness and musc

SUBMITTER: Sillanpaa E 

PROVIDER: S-EPMC8127311 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature