Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.

ABSTRACT: Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

SUBMITTER: Goddard ZR 

PROVIDER: S-EPMC8127329 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature