Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.
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ABSTRACT:
SUBMITTER: Goddard ZR
PROVIDER: S-EPMC8127329 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.
Goddard Zoë Rachael ZR Beekman Andrew Michael AM Cominetti Marco M D MMD O'Connell Maria A MA Chambrier Isabelle I Cook Michael J MJ Marín María J MJ Russell David A DA Searcey Mark M
RSC medicinal chemistry 20201119 2
Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity. ...[more]
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