Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection.

ABSTRACT:

Purpose

Perineural invasion (PNI) is associated with aggressive tumor behavior, recurrence, and metastasis, and can influence the administration of adjuvant treatment. However, standard histopathologic examination has limited sensitivity in detecting PNI and does not provide insights into its mechanistic underpinnings.

Experimental design

A multivariate Cox regression was performed to validate associations between PNI and survival in 2,029 patients across 12 cancer types. Differential expression and gene set enrichment analysis were used to learn PNI-associated programs. Machine learning models were applied to build a PNI gene expression classifier. A blinded re-review of hematoxylin and eosin (H&E) slides by a board-certified pathologist helped determine whether the classif

SUBMITTER: Guo JA 

PROVIDER: S-EPMC8127360 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature