SARS-CoV-2 seroprevalence among blood donors in Quebec, and analysis of symptoms associated with seropositivity: a nested case-control study.

ABSTRACT:

Objectives

A substantial proportion of individuals infected with SARS-CoV-2 do not experience noticeable symptoms typical of COVID-19. Our objectives were to evaluate the impact of the first wave of the pandemic in Québec by measuring SARS-CoV-2 antibody seroprevalence in a convenience sample of healthy blood donors and to study the association between seropositivity and the occurrence of COVID-19 symptoms.

Methods

The study design was a cross-sectional serological survey with a nested case-control study. Residual blood samples from donations collected between May 25 and July 9, 2020 (well before vaccination rollout) in the province of Québec were tested for anti-Spike RBD antibodies by ELISA. Seropositive donors and a control group of seronegative donors were questioned abo

SUBMITTER: Lewin A 

PROVIDER: S-EPMC8127462 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature