Pooled Testing Strategies for SARS-CoV-2 diagnosis: A comprehensive review.

ABSTRACT: SARS-CoV-2 has surged across the globe causing the ongoing COVID-19 pandemic. Systematic testing to facilitate index case isolation and contact tracing is needed for efficient containment of viral spread. The major bottleneck in leveraging testing capacity has been the lack of diagnostic resources. Pooled testing is a potential approach that could reduce cost and usage of test kits. This method involves pooling individual samples and testing them 'en bloc'. Only if the pool tests positive, retesting of individual samples is performed. Upon reviewing recent articles on this strategy employed in various SARS-CoV-2 testing scenarios, we found substantial diversity emphasizing the requirement of a common protocol. In this article, we review various theoretically simulated and clinically valida

SUBMITTER: Daniel EA 

PROVIDER: S-EPMC8127528 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature