RNA m⁶ A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection.

ABSTRACT:

Introduction

N⁶ -methyladenosine (m⁶ A) is the most prevalent modification that occurs in messenger RNA (mRNA), affecting mRNA splicing, translation, and stability. This modification is reversible, and its related biological functions are mediated by "writers," "erasers," and "readers." The field of viral epitranscriptomics and the role of m⁶ A modification in virus-host interaction have attracted much attention recently. When Epstein-Barr virus (EBV) infects a human B lymphocyte, it goes through three phases: the pre-latent phase, latent phase, and lytic phase. Little is known about the viral and cellular m⁶ A epitranscriptomes in EBV infection, especially in the pre-latent phase during de novo infection.

Methods

Methylated RNA im

SUBMITTER: Zheng X 

PROVIDER: S-EPMC8127537 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature