Oral birch pollen immunotherapy with apples: Results of a phase II clinical pilot study.

ABSTRACT:

Background

Seventy percent of patients suffering from birch pollen allergy (BPA) develop a pollen-related food allergy (prFA), especially to apples, due to a clinically relevant cross-reactivity between the major allergen in birch Bet v 1 and Mal d 1 in apples. Therefore allergen-specific immunotherapy with fresh apples (AITA) could be a promising natural treatment of both BPA and prFA.

Objective

To assess the clinical efficacy of immunotherapy by daily apple consumption for patients with BPA and prFA.

Methods

A daily defined increasing amount of selected cultivars (Red Moon®, Pink Lady®, Topaz, Golden Delicious) was continuously consumed by 16 patients (12 female; median age; 50; range, 23-68 years), leading to increased intake of allergen over a period of at least 8

SUBMITTER: Nothegger B 

PROVIDER: S-EPMC8127540 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature