Development of a prognostic index based on immunogenomic landscape analysis in glioma.

ABSTRACT:

Background

Glioma is the most common intracranial tumor. The inflammatory response actively participates in the malignancy of gliomas. There is still limited knowledge about the biological function of immune-related genes (IRGs) and their potential involvement in the malignancy of gliomas.

Methods

We screened differentially expressed and survival-associated IRGs, and explored their potential molecular characteristics. Then we developed a prognostic index derived from seven hub IRGs. A prognostic nomogram was built to indicate the prognostic value of the prognostic index and seven IRGs. We characterized the immune infiltration landscape to analyze tumor-immune interactions. The real-time quantitative polymerase chain reaction assay was performed to validate bioinformatics res

SUBMITTER: Luo H 

PROVIDER: S-EPMC8127549 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature