Kinetics and prognostic value of soluble VCAM-1 in ST-segment elevation myocardial infarction patients.

ABSTRACT:

Background

Soluble vascular cell adhesion molecule-1 (sVCAM-1) is a biomarker of endothelial activation and inflammation. There is still controversy as to whether it can predict clinical outcome after ST-elevation myocardial infarction (STEMI). Our aim was to assess the sVCAM-1 kinetics and to evaluate its prognostic predictive value.

Method

We prospectively enrolled 251 consecutive STEMI patients who underwent coronary revascularization in our university hospital. Blood samples were collected at admission, 4, 24, 48 h and 1 month after admission. sVCAM-1 serum level was assessed using ELISA assay. All patients had cardiac magnetic resonance imaging at 1-month for infarct size (IS) and left ventricular ejection fraction (LVEF) assessment. Clinical outcomes were recorded over

SUBMITTER: Hayek A 

PROVIDER: S-EPMC8127550 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature