Systemic immune responses in patients with early localized or early disseminated Borrelia afzelii lyme borreliosis.

ABSTRACT:

Introduction

The role of host immune responses in the pathogenesis of borrelial dissemination in early Lyme borreliosis (LB) in the form of multiple erythema migrans (MEM) or LB-associated symptoms is incompletely understood.

Methods

In this study, fifteen cytokine or chemokine levels, representative of innate, Th1, and Th17 immune responses, were assessed using a bead-based Luminex multiplex assay in acute sera from 76 adult patients with skin culture-positive Borrelia afzelii solitary erythema migrans (SEM) and 58 patients with MEM at a single-center university hospital. Differences between the groups were tested by modeling each cytokine or chemokine concentration by means of left-censored regression using the classic Tobit model.

Results

Mean serum cytokine or che

SUBMITTER: Cerar Kisek T 

PROVIDER: S-EPMC8127568 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature