Secretion rates and protein composition of extracellular vesicles released by cancer-associated fibroblasts after radiation.

ABSTRACT: Reciprocal communication between the malignant and non-malignant cellular elements in tumors is essential for cancer sustainability and plays an important role in the response of cancers to treatments. Some of this cellular crosstalk takes place via secretion of vesicles that are actively released into the extracellular space by most cell types in tumors. Recent studies have demonstrated radiation-induced changes in the secretion rate and composition of extracellular vesicles (EVs), with impact on radiation-related cellular communication. However, little is known about the effects of different radiation regimens on the release of EVs by cells of the tumor microenvironment. In this study, we provide a comprehensive molecular characterization of EVs released by cultured primary lung tumor fi

SUBMITTER: Berzaghi R 

PROVIDER: S-EPMC8127688 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature