Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases.

ABSTRACT: We performed a systematic literature review to summarize the underlying pathogenic mechanisms by which adipokines influence rheumatological diseases and the resulting clinical manifestations. Increasing evidence display that numerous adipokines may significantly influence the development or clinical course of various rheumatological diseases. Despite the normal anti- or pro-inflammatory role of the cytokines, the serum level varies enormously in various rheumatological diseases. The expression of high levels of pro-inflammatory cytokines such as leptin or visfatin, respectively in systemic lupus erythematosus and in rheumatoid arthritis, represents a negative prognostic factor; other adipokines such as adiponectin, broadly known for their anti-inflammatory effects, showed a correlation wit

SUBMITTER: Giardullo L 

PROVIDER: S-EPMC8127732 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature