Identification of men with low-risk biopsy-confirmed prostate cancer as candidates for active surveillance.

ABSTRACT:

Background

A combined clinical cell-cycle risk (CCR) score that incorporates prognostic molecular and clinical information has been recently developed and validated to improve prostate cancer mortality (PCM) risk stratification over clinical features alone. As clinical features are currently used to select men for active surveillance (AS), we developed and validated a CCR score threshold to improve the identification of men with low-risk disease who are appropriate for AS.

Methods

The score threshold was selected based on the 90th percentile of CCR scores among men who might typically be considered for AS based on NCCN low/favorable-intermediate risk criteria (CCR = 0.8). The threshold was validated using 10-year PCM in an unselected, conservatively managed cohort and in the

SUBMITTER: Lin DW 

PROVIDER: S-EPMC8127807 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature