The relationship between PLOD1 expression level and glioma prognosis investigated using public databases.

ABSTRACT:

Background

Glioma is the most common type of intracranial tumor with high malignancy and poor prognosis despite the use of various aggressive treatments. Targeted therapy and immunotherapy are not effective and new biomarkers need to be explored. Some Procollagen-lysine 2-oxyglutarate 5-dioxygenase (PLOD) family members have been found to be involved in the metastasis and progression of tumors. Both PLOD2 and PLOD3 had been reported to be highly expressed in gliomas, while the prognostic value of PLOD1 remains to be further illustrated, so we want to investigate the PLOD1 expression in glioma and its clinical implication.

Methods

We collected gene expression and corresponding clinical data of glioma from the Chinese Glioma Genome Atlas (CGG

SUBMITTER: Tian L 

PROVIDER: S-EPMC8127981 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature