Hippocampal activation during contextual fear inhibition related to resilience in the early aftermath of trauma.

ABSTRACT:

Background

Impaired contextual fear inhibition is often associated with posttraumatic stress disorder (PTSD). Our previous work has demonstrated that more hippocampal activation during a response inhibition task after trauma exposure was related to greater resilience and fewer future PTSD symptoms. In the current study, we sought to extend our previous findings by employing a contextual fear conditioning and extinction paradigm to further determine the role of the hippocampus in resilience and PTSD in the early aftermath of trauma.

Methods

Participants (N = 28) were recruited in the Emergency Department shortly after experiencing a traumatic event. A contextual fear inhibition task was conducted in a 3 T MRI scanner approximately two months post-trauma. Measures of resilienc

SUBMITTER: van Rooij SJH 

PROVIDER: S-EPMC8128041 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature