Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability.
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ABSTRACT:
SUBMITTER: Borsari C
PROVIDER: S-EPMC8128076 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability.
Borsari Chiara C Keles Erhan E Treyer Andrea A De Pascale Martina M Hebeisen Paul P Hamburger Matthias M Wymann Matthias P MP
RSC medicinal chemistry 20210112 4
Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound <b>11</b> showed predicted BBB permeability in a MDCK-MDR1 permeability <i>in vitro</i> assay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurological disorders. ...[more]
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