Inhibition of RANK signaling as a potential immunotherapy in breast cancer.

ABSTRACT: RANK signaling in mouse mammary tumor cells exerts an immunosuppressive environment by promoting the infiltration of pro-tumorigenic neutrophils and preventing CD8 T cell recruitment. Single-agent denosumab led to an increased tumor immune infiltration by lymphocytes and CD8 + T cells in breast cancer patients, supporting the immunomodulatory role of RANK signaling.

SUBMITTER: Gomez-Aleza C 

PROVIDER: S-EPMC8128215 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature