Inhibition of RANK signaling as a potential immunotherapy in breast cancer.
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ABSTRACT:
SUBMITTER: Gomez-Aleza C
PROVIDER: S-EPMC8128215 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Inhibition of RANK signaling as a potential immunotherapy in breast cancer.
Gómez-Aleza C C González-Suárez E E
Oncoimmunology 20210514 1
RANK signaling in mouse mammary tumor cells exerts an immunosuppressive environment by promoting the infiltration of pro-tumorigenic neutrophils and preventing CD8 T cell recruitment. Single-agent denosumab led to an increased tumor immune infiltration by lymphocytes and CD8 + T cells in breast cancer patients, supporting the immunomodulatory role of RANK signaling. ...[more]
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