Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study.

ABSTRACT:

Background

In patients with resectable colorectal liver metastases (CRLM), the role of pre- and postoperative systemic therapy continues to be debated. Previous studies have shown that circulating tumor DNA (ctDNA) analysis, as a marker of minimal residual disease, is a powerful prognostic factor in patients with nonmetastatic colorectal cancer (CRC). Serial analysis of ctDNA in patients with resectable CRLM could inform the optimal use of perioperative chemotherapy. Here, we performed a validation study to confirm the prognostic impact of postoperative ctDNA in resectable CRLM observed in a previous discovery study.

Methods and findings

We prospectively collected plasma samples from patients with resectable CRLM, including presurgical and postsurgical samples, serial sample

SUBMITTER: Tie J 

PROVIDER: S-EPMC8128260 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature