Cortisol effects on brain functional connectivity during emotion processing in women with depression.

ABSTRACT:

Background

Depression is associated with altered functional connectivity and altered cortisol sensitivity, but the effects of cortisol on functional connectivity in depression are unknown. Previous research shows that brief cortisol augmentation (CORT) has beneficial neurocognitive effects in depression.

Methods

We investigated the effects of CORT (20mg oral cortisol) on functional connectivity during emotion processing in women with depression. Participants included 75 women with no depression or a depressive disorder. In a double-blind, crossover study, we used functional magnetic resonance imaging to measure effects of CORT vs. placebo on task-based functional connectivity during presentation of emotionally-laden images. We performed psychophysiological interaction (PPI)

SUBMITTER: Rivera-Bonet CN 

PROVIDER: S-EPMC8128282 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature