Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris.

ABSTRACT: Candida auris is an emerging fungal pathogen of rising concern due to global spread, the ability to cause healthcare-associated outbreaks, and antifungal resistance. Genomic analyses revealed that early contemporaneously detected cases of C. auris were geographically stratified into four major clades. While Clades I, III, and IV are responsible for ongoing outbreaks of invasive and multidrug-resistant infections, Clade II, also termed the East Asian clade, consists primarily of cases of ear infection, is often susceptible to all antifungal drugs, and has not been associated with outbreaks. Here, we generate chromosome-level assemblies of twelve isolates representing the phylogenetic breadth of these four clades and the only isolate described to date from Clade V. This Clade V genome is hig

SUBMITTER: Munoz JF 

PROVIDER: S-EPMC8128392 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature