Yield of Random Biopsies During Colonoscopies in Inflammatory Bowel Disease Patients Undergoing Dysplasia Surveillance.

ABSTRACT:

Background

The development of chromoendoscopy (CE) and high definition endoscopy (HDE) has improved detection of subtle colonic dysplasia in patients with inflammatory bowel diseases (IBDs). The role of random biopsies for dysplasia surveillance is unclear.

Methods

We reviewed patients with IBD who underwent a CE or HDE colonoscopy and had colonic dysplasia detected. Detection of dysplasia was classified as either visible or random and graded as low grade dysplasia (LGD), high grade dysplasia (HGD), or indefinite for dysplasia. Multivariable regression adjusted for relevant confounders examined the predictors of dysplasia detectable on random biopsies alone.

Results

The study included 300 patients (203 ulcerative colitis, 97 Crohn's disease with colonic involvement) c

SUBMITTER: Hu AB 

PROVIDER: S-EPMC8128394 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature