Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK.

ABSTRACT:

Background

Inflammatory bowel diseases are the most common chronic intestinal inflammatory conditions, and their incidence has shown a dramatic increase in recent decades. Limited efficacy and questionable safety profiles with existing therapies suggest the need for better targeting of therapeutic strategies. Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of cellular metabolism and has been implicated in intestinal inflammation. Macrophages execute an important role in the generation of intestinal inflammation. Impaired AMPK in macrophages has been shown to be associated with higher production of proinflammatory cytokines; however, the role of macrophage AMPK in intestinal inflammation and the mechanism by which it regulates inflammation remain to be det

SUBMITTER: Banskota S 

PROVIDER: S-EPMC8128406 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature