Neutrophil extracellular traps promote gastric cancer metastasis by inducing epithelial‑mesenchymal transition.

ABSTRACT: The risks of tumor recurrence following the successful resection of the primary tumor have been known for decades; however, the precise mechanisms underlying treatment failures remain unknown. The formation of neutrophil extracellular traps (NETs) has increasingly been demonstrated to be associated with thrombi formation in cancer patients, as well as with the development and metastasis of cancer. The present study demonstrated that the level of peripheral blood NETs in patients with gastric cancer (GC) was associated with tumor progression, and patients with stage III/IV disease exhibited significant differences compared with the healthy controls and patients with stage I/II disease, which may be associated with an increased risk of metastasis. In addition, plasma from patients with stage

SUBMITTER: Zhu T 

PROVIDER: S-EPMC8128417 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature