FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data.

ABSTRACT:

Motivation

Transcriptomics dose-response analysis is a promising new approach method for toxicity testing. While international regulatory agencies have spent substantial effort establishing a standardized statistical approach, existing software that follows this approach is computationally inefficient and must be locally installed.

Results

FastBMD is a web-based tool that implements standardized methods for transcriptomics benchmark dose-response analysis in R. It is >60 times faster than the current leading software, supports transcriptomics data from 13 species, and offers a comprehensive analytical pipeline that goes from processing and normalization of raw gene expression values to interactive exploration of pathway-level benchmark dose results.

Availability and imple

SUBMITTER: Ewald J 

PROVIDER: S-EPMC8128449 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature